HORDB

ID: hor004603
Uniprot ID: Q9DFJ9
Protein name: Thymosin beta
Gene name: NA
Organism: Gillichthys mirabilis (Long-jawed mudsucker)
Family: Thymosin beta family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Gillichthys (genus), Gobionellinae (subfamily), Gobiidae (family), Gobioidei (suborder), Gobiiformes (order), Gobiaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004603_AF2.pdb

hor004603_ESM.pdb

Mass:	553253	Formula:	C203H338N54O78
Absent amino acids:	ACHMRWY	Common amino acids:	K
pI:	4.65	Basic residues:	8
Polar residues:	15	Hydrophobic residues:	7
Hydrophobicity:	-142.56	Boman Index:	-13881
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	47.44
Instability Index:	2807.21	Extinction Coefficient cystines:	0
Absorbance 280nm:	0